Nolvadex - a brand for drugs based on the active ingredient tamoxifen citrate.
This is a non-steroid substance, which has anti-estrogenic properties. This property is explained by the ability of the substance to compete with estrogen in various tissues. In medical practice, the effect is very beneficial in the treatment of patients with tumors caused by the action of estrogen.
Bodybuilders (men) find Nolvadex very effective in combating the consequence of taking steroids with a strong level of aromatization leading to an increase in the level of estrogen.
Without correction or post-course therapy, for example, gynecomastia and fat formation may develop.
Nolvadex, or rather - Tamoxifen citrate, works by blocking the estrogen receptors, as a result of the use of nolvadex, the negative development of the breast on the chest is solidly reduced and can stop completely.
The drug is almost non-toxic and does not give almost no negative effects.
The drug fits well into most of the anabolic courses, as a counterweight to possible side effects. It should be noted that Nolvadex is able to slow the progress of genicomastia during the steroid course. This can be explained by the fact that estrogen plays the assigned task in maintaining open androgen receptors. Regardless of this, Nolvadex is considered the most famous anti-estrogen used by male athletes.
Nolvadex principle of work
Nolvadex (Tamoxifen) does not affect the level of estrogens in the blood, because The mechanism of its action is reduced to blockade of different types of estrogen receptors. Thus, it is possible to speak of tamoxifen citrate as not selective (not selective). Nolvadex binds to estrogen receptors throughout the body. By blocking the receptors throughout the body, it helps the body begin to restore its own testosterone. It is important to note that Nolvadex is able to block estrogen receptors in the pituitary gland to a lesser degree than Clomid.
Nolvadex reception, digestion and excretion
When taken orally, the drug is rapidly absorbed, and after 5-7 hours the highest concentration is made in the blood. The drug is 99% interacting with blood proteins (albumin).
Excretion from the body is biphasic:
- initial T 1/2 from 8 to 14 h
- final T 1/2 - 7 days
&nThe onset of reception of Nolvadex occurs at 2 weeks of the steroid cycle and ends 2-3 weeks after the end of the cycle, with an average dose of 10-20 mg per day.
Pay attention to the common misconception that anti-estrogens should be drunk after a cycle. This is not true!!!
The level of estrogen rises at the end of the first week of the cycle of taking anabolic medications, so it is from this point on that you need to start taking it!
If anabolic drugs are used that are slightly susceptible to aromatization, then the need for aromatase inhibitors during the course is eliminated, and Tamoxifen citrate (Nolvadex) is included only at the end of the course.
Nolvadex drug belongs to the group of anti-tumor drugs. However, this drug is widely used men who are engaged in bodybuilding and want to pump up muscles. Since Nolvadex contains an active ingredient tamoxifen, which is a selective estrogen receptor modulator mixed agonistic and antagonistic properties. This means that in certain tissue, they block the action of estrogen receptors by binding, while in other tissues could act as a real estrogen receptors activating. In men, both drugs act as anti-estrogens in their ability to interfere with estrogen negative feedback on the hypothalamus and stimulate the increased production of GnRH (gonadotropin-releasing hormone). This will result in increased production of luteinizing hormone by the pituitary gland, which in turn can increase the production of testosterone by the testes. This makes both drugs, but for some reason bodybuilders continue to think that only Clomid is well suited to the stimulation of testosterone.
According to studies of the drug, the effect of Nolvadex and Clomid on the endocrine system of healthy men suffering from low sperm counts (oligospermia), have shown the benefits of Nolvadex over Clomid to increase testosterone levels. The drug also has no effect on the blood level of estrogens because its mechanism of action is also reduced to the estrogen receptor blockade, including the pituitary gland. However, Nolvadex - less selective as compared to other drugs of this series. Nolvadex binds to estrogen receptors in almost all the body. In bone tissue, tamoxifen activates the estrogen receptors.
Nolvadex blocks the receptors in almost all tissues and helps to ensure that the body began to rebuild its own testosterone. Importantly, Nolvadex capable of blocking estrogen receptors in the pituitary less drug than Clomid. Nolvadex does not affect the metabolism of estrogenic hormones, so the intake of estrogens these means continue to erode the liver enzymes, and do not accumulate in the body.
Taking the drug with caution, since toxic and Nolvadex belongs to the group of the banned doping agents. Although it is widely used in bodybuilding men. Also, this pills is antiestrogen, an antitumor agent based on active ingredient tamoxifen for the treatment of malignant tumors of breast and endometrial malignancy.